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Swollen Joint

A two year old girl is referred to clinic with an eight week history of a swollen right ankle. Her parents have noticed that she is asking to be carried more often but she remains generally well.

pGALS demonstrates no joint involvement elsewhere but she has got calf wasting (right side).

Differential diagnosis
This girl is likely to have oligoarticular JIA but initial investigations must exclude other possible diagnoses, including septic arthritis and malignancy

Red flags would include systemic upset (such as fever, weight loss, night pain, pallor, lymphadenopathy, bone tenderness).  The presence of calf wasting suggests chronicity and in the presence of a well child, suggests JIA more likely.  

The photograph below shows a swollen right ankle and calf wasting on the right side. 

Complete blood count: this should be normal in a child with oligoarticular JIA and one swollen joint. A low haemoglobin, low white cell count or platelets should raise the possibility of haematological malignancy such as leukaemia and further investigations including blood film and bone marrow aspirate may be required. Significantly elevated neutrophil or platelet count may indicate underlying infection and further investigations including blood cultures and synovial fluid aspiration may be required.

Acute phase reactants: Significantly elevated acute phase reactants (ESR or CRP) are unusual in oligoarticular JIA and should trigger further investigations to exclude infection (including reactive arthritis) and /or malignancy.

Anti-nuclear antibody (ANA): A positive ANA can occur in JIA and is associated with an increased risk of uveitis. Although all children with JIA are at risk from uveitis, young children, particularly girls, with persistently positive ANA are at higher risk. ANA is not diagnostic of JIA, can be observed in normal healthy children or with intercurrent illness.

Slit Lamp Examination - Prompt referral for eye screening is needed as she may have chronic anterior uveitis, whether she is ANA positive or not. She is at high risk of chronic anterior uveitis given her age, and clinical presentation.

Rheumatoid factor: RF is unlikely to be positive in children with oligoarticular JIA.

HLA B27: There are HLA associations for each JIA subtype, particularly important in oligoarticular disease. HLA B27 plays an important role in the classification of JIA and is associated with both enthesitis related arthritis and psoriatic arthritis. HLA B27 positivity predicts more aggressive disease and the likelihood of acute uveitis with a painful red eye. HLA B27 is useful in the assessment of the older child with peripheral arthritis predominantly involving the lower limb or in the presence of enthesitis or sacroiliitis.

Plain radiograph: May show erosive disease in late presentations but usually radiographs will be normal in early presentation of JIA. Radiographs are indicated if there is any suggestion of physical trauma. If non-accidental injury is suspected then a skeletal survey may be needed to look for injuries elsewhere (e.g. ribs, long bones).

Ultrasound scan (USS): If available, then USS can be very useful in determining the presence of sub-clinical synovitis and/or tenosynovitis.

Magnetic Resonance Imaging (MRI): May be useful in children with unusual presentations or long standing disease in which it can be difficult to differentiate between damage and active synovitis. MRI is very useful where joints are less accessible (such as hips, shoulders) or where there is clinical uncertainty (such as ankle, subtalar joints) or to exclude other diagnoses (e.g. meniscal injury, villonodular synovitis, tumour).

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