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What is the diagnosis?

This may be a multisystem illness but infection and malignancy need to be excluded with blood tests (full blood count, film), acute phase reactants, autoantibodies, complement (C3,C4), thyroid function and urinalysis. She has polyarthralgia predominantly. 

Investigations demonstrated features consistent with JSLE (mild lymphopenia, low C3 and C4. ANA positive and ds DNA positive). ESR was raised (35mm/hr) but CRP normal. Urinalysis was negative. Other tests were negative.  

She was started on hydroxychloroquine to help joint pain. 

She remained well but 3 months later developed more malaise, alopecia and joint pain. Repeat blood tests showed increase ds DNA, worse lymphopenia, anaemia and urinalysis showed proteinuria and haematuria. Her blood pressure was normal. She was admitted for assessment and had a renal biopsy which demonstrated glomerulonephritis (WHO Class IV). She was started on IV corticosteroids and cyclophosphamide (to be given over a series of months as a day case on subsequent visits).

Whilst as an inpatient she had considerable input from the nurse and doctor to explain her disease, treatment and advice for when she was discharged home on oral corticosteroids and when to seek medical advice if she developed a fever or was unwell. She had many concerns about her corticosteroids and potential for weight gain.  She was much better after her initial treatment and had regular input from the nurses and therapists who liased with school about her illness, coping with her medication and need for regular appointments. 

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