What is the significance of HLA B27?
The presence of HLA B27 is common in many healthy people.
In the presence of inflammatory arthritis, it can associate with axial spine involvement (which may present later on with pain / stiffness in the neck or lower back) and acute uveitis (which will cause a painful red eye and is different to the chronic anterior uveitis observed in many cases of JIA). This has implications for monitoring and eye screening.
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